Depends, depends, depends. As has been said already.
I pack my vinos pretty tight, so I have 2 lbs in each. One on the bottom and one about 2/3 the way to the top. I have a single fan that I am considering removing. I'm in Portland, OR, where it is cool and humid lots of the year. I expect to leave my vinos unplugged for about 8 months out of 12. I have not plugged the drain, but plan to put duct tape over the drain during the next "great tetris game" which should be soon (as opposed to the one last weekend).
Since I've had the vinos, I've had problems with draw. I've found that putting a range of sticks into the Savoy 300 ct for more than a week (with about 1/4lb of beads, not dryboxing) helps immensely.